Ontology highlight
ABSTRACT:
SUBMITTER: Verghese J
PROVIDER: S-EPMC2714770 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Verghese Jenson J Liang Aiye A Sidhu Preet Pal Singh PP Hindle Michael M Zhou Qibing Q Desai Umesh R UR
Bioorganic & medicinal chemistry letters 20090606 15
Designing non-saccharide functional mimics of heparin is a major challenge. In this work, a library of small, aromatic molecules based on the sulfated DHP scaffold was synthesized and screened against thrombin and factor Xa. The results reveal that (i) selected monomeric benzofuran derivatives inhibit the two enzymes, albeit weakly; (ii) the two enzymes recognize different structural features in the benzofurans studied suggesting significant selectivity of recognition; and (iii) the mechanism of ...[more]