Ontology highlight
ABSTRACT:
SUBMITTER: Heinze RJ
PROVIDER: S-EPMC2715241 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Heinze Roger J RJ Giron-Monzon Luis L Solovyova Alexandra A Elliot Sarah L SL Geisler Sven S Cupples Claire G CG Connolly Bernard A BA Friedhoff Peter P
Nucleic acids research 20090527 13
DNA mismatch repair (MMR) and very-short patch (VSP) repair are two pathways involved in the repair of T:G mismatches. To learn about competition and cooperation between these two repair pathways, we analyzed the physical and functional interaction between MutL and Vsr using biophysical and biochemical methods. Analytical ultracentrifugation reveals a nucleotide-dependent interaction between Vsr and the N-terminal domain of MutL. Using chemical crosslinking, we mapped the interaction site of Mut ...[more]