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Wild birds of declining European species are dying from a thiamine deficiency syndrome.


ABSTRACT: Wild birds of several species are dying in large numbers from an idiopathic paralytic disease in the Baltic Sea area. Here, we demonstrate strong relationships between this disease, breeding failure, and thiamine (vitamin B(1)) deficiency in eggs, pulli, and full-grown individuals. Thiamine is essential for vertebrates, and its diphosphorylated form functions as a cofactor for several life sustaining enzymes, whereas the triphosphorylated form is necessary for the functioning of neuronal membranes. Paralyzed individuals were remedied by thiamine treatment. Moreover, thiamine deficiency and detrimental effects on thiamine-dependent enzymes were demonstrated in the yolk, liver, and brain. We propose that the mortality and breeding failure are part of a thiamine deficiency syndrome, which may have contributed significantly to declines in many bird populations during the last decades.

SUBMITTER: Balk L 

PROVIDER: S-EPMC2715476 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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Wild birds of declining European species are dying from a thiamine deficiency syndrome.

Balk Lennart L   Hägerroth Per-Ake PA   Akerman Gun G   Hanson Marsha M   Tjärnlund Ulla U   Hansson Tomas T   Hallgrimsson Gunnar Thor GT   Zebühr Yngve Y   Broman Dag D   Mörner Torsten T   Sundberg Henrik H  

Proceedings of the National Academy of Sciences of the United States of America 20090713 29


Wild birds of several species are dying in large numbers from an idiopathic paralytic disease in the Baltic Sea area. Here, we demonstrate strong relationships between this disease, breeding failure, and thiamine (vitamin B(1)) deficiency in eggs, pulli, and full-grown individuals. Thiamine is essential for vertebrates, and its diphosphorylated form functions as a cofactor for several life sustaining enzymes, whereas the triphosphorylated form is necessary for the functioning of neuronal membran  ...[more]

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