Ontology highlight
ABSTRACT:
SUBMITTER: Markov GV
PROVIDER: S-EPMC2715501 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Markov Gabriel V GV Tavares Raquel R Dauphin-Villemant Chantal C Demeneix Barbara A BA Baker Michael E ME Laudet Vincent V
Proceedings of the National Academy of Sciences of the United States of America 20090701 29
Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we ...[more]