Ontology highlight
ABSTRACT:
SUBMITTER: Swensen JS
PROVIDER: S-EPMC2715559 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Swensen James S JS Xiao Yi Y Ferguson Brian S BS Lubin Arica A AA Lai Rebecca Y RY Heeger Alan J AJ Plaxco Kevin W KW Soh H Tom HT
Journal of the American Chemical Society 20090401 12
The development of a biosensor system capable of continuous, real-time measurement of small-molecule analytes directly in complex, unprocessed aqueous samples has been a significant challenge, and successful implementation has been achieved for only a limited number of targets. Toward a general solution to this problem, we report here the Microfluidic Electrochemical Aptamer-based Sensor (MECAS) chip wherein we integrate target-specific DNA aptamers that fold, and thus generate an electrochemica ...[more]