Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.
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ABSTRACT:
SUBMITTER: Stewart PS
PROVIDER: S-EPMC2715639 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
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Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.
Stewart Philip S PS Davison William M WM Steenbergen Judith N JN
Antimicrobial agents and chemotherapy 20090518 8
Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm. ...[more]
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