Ontology highlight
ABSTRACT:
SUBMITTER: Speer MY
PROVIDER: S-EPMC2716055 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Speer Mei Y MY Yang Hsueh-Ying HY Brabb Thea T Leaf Elizabeth E Look Amy A Lin Wei-Ling WL Frutkin Andrew A Dichek David D Giachelli Cecilia M CM
Circulation research 20090205 6
Vascular calcification is a major risk factor for cardiovascular morbidity and mortality. To develop appropriate prevention and/or therapeutic strategies for vascular calcification, it is important to understand the origins of the cells that participate in this process. In this report, we used the SM22-Cre recombinase and Rosa26-LacZ alleles to genetically trace cells derived from smooth muscle. We found that smooth muscle cells (SMCs) gave rise to osteochondrogenic precursor- and chondrocyte-li ...[more]