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Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects.

ABSTRACT: The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F approximately CO2tBu < CN < H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

SUBMITTER: Ratnakar SJ 

PROVIDER: S-EPMC2716115 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects.

Ratnakar S James SJ   Woods Mark M   Lubag Angelo J M AJ   Kovacs Zoltan Z   Sherry A Dean AD  

Journal of the American Chemical Society 20071208 1

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me < MeO < F approximately CO2tBu < CN < H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and red  ...[more]

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