Ontology highlight
ABSTRACT:
SUBMITTER: Rosenthal RA
PROVIDER: S-EPMC2716445 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Rosenthal Rosalind A RA Huffman Karl D KD Fisette Leslie W LW Damphousse Christy A CA Callaway Wyeth B WB Malfroy Bernard B Doctrow Susan R SR
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090606 6
Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn porphyrins, have been shown to be orally bioavailable. In this study, EUK-418 and several new analogs (the EUK-400 series) were synthes ...[more]