Symbiotic bacteria direct expression of an intestinal bactericidal lectin.
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ABSTRACT:
SUBMITTER: Cash HL
PROVIDER: S-EPMC2716667 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
Publications
Symbiotic bacteria direct expression of an intestinal bactericidal lectin.
Cash Heather L HL Whitham Cecilia V CV Behrendt Cassie L CL Hooper Lora V LV
Science (New York, N.Y.) 20060801 5790
The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIgamma, a secreted C-type lectin. RegIIIgamma binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-type lectins. We show that RegIIIgamma and its human counterpart, HIP/PAP, are directly antimicrobial prot ...[more]
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