Ontology highlight
ABSTRACT:
SUBMITTER: Weng J
PROVIDER: S-EPMC2717296 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Biophysical journal 20090301 5
Putative metal-chelate-type ABC transporter HI1470/1 is homologous with vitamin B(12) importer BtuCD but exhibits a distinct inward-facing conformation in contrast to the outward-facing conformation of BtuCD. Normal-mode analysis of HI1470/1 reveals the intrinsic asymmetric conformational flexibility in this transporter and demonstrates that the transition from the inward-facing to the outward-facing conformation is realized through the asymmetric motion of individual subunits of the transporter ...[more]