Ontology highlight
ABSTRACT:
SUBMITTER: Tuteja R
PROVIDER: S-EPMC2717535 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Communicative & integrative biology 20090501 3
Protein synthesis in eukaryotes initiates with binding of the multisubunit translation initiation complex eIF4F. This complex contains eIF4E, eIF4A and eIF4G. eIF4E directly interacts with the cap structure, eIF4A is an RNA helicase and eIF4G acts as a scaffold for the complex. eIF4G contains the binding sites for both the subunits i.e., eIF4A and eIF4E and it also interacts with poly(A)-binding protein (PABP). In present study we have identified and characterized the main components of the eIF4 ...[more]