Ontology highlight
ABSTRACT:
SUBMITTER: Novak IL
PROVIDER: S-EPMC2718152 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Novak Igor L IL Kraikivski Pavel P Slepchenko Boris M BM
Biophysical journal 20090801 3
The intricate geometry of cytoskeletal networks and internal membranes causes the space available for diffusion in cytoplasm to be convoluted, thereby affecting macromolecule diffusivity. We present a first systematic computational study of this effect by approximating intracellular structures as mixtures of random overlapping obstacles of various shapes. Effective diffusion coefficients are computed using a fast homogenization technique. It is found that a simple two-parameter power law provide ...[more]