Physiologic, biochemical, and imaging characterization of acute lung injury in mice.

ABSTRACT:

Rationale

Most models of acute lung injury in mice have yet to be fully characterized.

Objectives

To directly compare and contrast endotoxin and oleic acid models of acute lung injury in mice in terms of their physiologic, biochemical, histopathologic, and imaging manifestations.

Methods

Survival studies, lung weights, x-ray computed tomographic scanning, light and electron microscopy, bronchoalveolar lavage, lung uptake of ((18)F)fluorodeoxyglucose, tissue myeloperoxidase, arterial blood gases, mean arterial pressure, and lung tissue prostanoids were measured in separate groups of C57Bl/6 mice (normal animals, endotoxin only [20 microg/g], oleic acid only [0.15 microl/g], or endotoxin + oleic acid).

Results

Endotoxin alone caused only mild pulmonary neutrophil

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC2718473 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature