Ontology highlight
ABSTRACT:
SUBMITTER: Tabuchi K
PROVIDER: S-EPMC2719251 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Tabuchi Katsuhiko K Chen Guiquan G Südhof Thomas C TC Shen Jie J
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090601 22
Loss of presenilin function in adult mouse brains causes memory loss and age-related neurodegeneration. Since presenilin possesses gamma-secretase-dependent and -independent activities, it remains unknown which activity is required for presenilin-dependent memory formation and neuronal survival. To address this question, we generated postnatal forebrain-specific nicastrin conditional knock-out (cKO) mice, in which nicastrin, a subunit of gamma-secretase, is inactivated selectively in mature exci ...[more]