Ontology highlight
ABSTRACT:
SUBMITTER: Kochaniak AB
PROVIDER: S-EPMC2719409 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090503 26
Proliferating cell nuclear antigen (PCNA) plays an important role in eukaryotic genomic maintenance by topologically binding DNA and recruiting replication and repair proteins. The ring-shaped protein forms a closed circle around double-stranded DNA and is able to move along the DNA in a random walk. The molecular nature of this diffusion process is poorly understood. We use single-molecule imaging to visualize the movement of individual, fluorescently labeled PCNA molecules along stretched DNA. ...[more]