Ontology highlight
ABSTRACT:
SUBMITTER: Al-Rashid ZF
PROVIDER: S-EPMC2720040 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20081021 22
A de novo preparation of alpha-keto-imides via ynamide oxidation is described. With a number of alkyne oxidation conditions screened, a highly efficient RuO2-NaIO4 mediated oxidation and a DMDO oxidation have been identified to tolerate a wide range of ynamide types. In addition to accessing a wide variety of alpha-keto-imides, the RuO2-NaIO4 protocol provides a novel entry to the vicinal tricarbonyl motif via oxidation of push-pull ynamides, and imido acylsilanes from silyl-substituted ynamides ...[more]