Ontology highlight
ABSTRACT:
SUBMITTER: Likitvivatanavong S
PROVIDER: S-EPMC2720071 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
FEBS letters 20090518 12
Using a Cry11Ba toxin model, predicted loops in domain II were analyzed for their role in receptor binding and toxicity. Peptides corresponding to loops alpha8, 1 and 3, but not loop 2, competed with toxin binding to Aedes midgut membranes. Mutagenesis data reveal loops alpha8, 1 and 3 are involved in toxicity. Loops 1 and 3 are of greater significance in toxicity to Aedes and Culex larvae than to Anopheles. Cry11Ba binds the apical membrane of larval caecae and posterior midgut, and binding can ...[more]