Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder.
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ABSTRACT:
SUBMITTER: Cornelius JR
PROVIDER: S-EPMC2720419 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorder.
Cornelius Jack R JR Bukstein Oscar G OG Wood D Scott DS Kirisci Levent L Douaihy Antoine A Clark Duncan B DB
Addictive behaviors 20090312 10
<h4>Objective</h4>This study compared the acute phase (12-week) efficacy of fluoxetine versus placebo for the treatment of the depressive symptoms and the drinking of adolescents with comorbid major depression (MDD) and an alcohol use disorder (AUD). We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of both the depressive symptoms and the drinking of comorbid MDD/AUD adolescents.<h4>Methods</h4>We conducted the first double-blind placebo-controlled study ...[more]
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