Ontology highlight
ABSTRACT:
SUBMITTER: Hyde JE
PROVIDER: S-EPMC2720532 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Hyde John E JE Dittrich Sabine S Wang Ping P Sims Paul F G PF de Crécy-Lagard Valérie V Hanson Andrew D AD
Trends in parasitology 20080919 11
Folates have a key role in metabolism, and the folate-dependent generation of DNA precursors in the form of deoxythymidine 5'-phosphate is particularly important for the replication of malaria parasites. Although Plasmodium falciparum can synthesize folate derivatives de novo, a long-standing mystery has been the apparent absence of a key enzyme, dihydroneopterin aldolase, in the classical folate biosynthetic pathway of this organism. The discovery that a different enzyme, pyruvoyltetrahydropter ...[more]