Combined chemical and biosynthetic route to access a new apoptolidin congener.
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ABSTRACT:
SUBMITTER: Ghidu VP
PROVIDER: S-EPMC2720611 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Combined chemical and biosynthetic route to access a new apoptolidin congener.
Ghidu Victor P VP Ntai Ioanna I Wang Jingqi J Jacobs Aaron T AT Marnett Lawrence J LJ Bachmann Brian O BO Sulikowski Gary A GA
Organic letters 20090701 14
Glycosylation of a synthetic aglycone using precursor-directed biosynthesis is facilitated by a chemical ketosynthase "knockdown" of the apoptolidin producer Nocardiopsis sp. This synthetic approach facilitated the preparation of an unnatural disaccharide derivative of apoptolidin D that substantially restores cytotoxicity against H292 cells and deconvolutes the role of the decorating sugars in apoptolidin bioactivity. ...[more]
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