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Specific gene hypomethylation and cancer: new insights into coding region feature trends.


ABSTRACT: Giving coding region structural features a role in the hypomethylation of specific genes, the occurrence of G+C content, CpG islands, repeat and retrotransposable elements in demethylated genes related to cancer has been evaluated. A comparative analysis among different cancer types has also been performed. In this work, the inter-cancer coding region features comparative analysis carried out, show insights into what structural trends/patterns are present in the studied cancers.

SUBMITTER: Daura-Oller E 

PROVIDER: S-EPMC2720671 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Specific gene hypomethylation and cancer: new insights into coding region feature trends.

Daura-Oller Elias E   Cabre Maria M   Montero Miguel A MA   Paternain Jose L JL   Romeu Antoni A  

Bioinformation 20090421 8


Giving coding region structural features a role in the hypomethylation of specific genes, the occurrence of G+C content, CpG islands, repeat and retrotransposable elements in demethylated genes related to cancer has been evaluated. A comparative analysis among different cancer types has also been performed. In this work, the inter-cancer coding region features comparative analysis carried out, show insights into what structural trends/patterns are present in the studied cancers. ...[more]

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