Ontology highlight
ABSTRACT:
SUBMITTER: Dong B
PROVIDER: S-EPMC2721020 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Dong Bingning B Qatanani Mohammed M Moore David D DD
Hepatology (Baltimore, Md.) 20090801 2
<h4>Unlabelled</h4>Untreated type 1 diabetes increases hepatic drug metabolism in both human patients and rodent models. We used knockout mice to test the role of the nuclear xenobiotic receptors constitutive androstane receptor (CAR) and pregnane and xenobiotic receptor (PXR) in this process. Streptozotocin-induced diabetes resulted in increased expression of drug metabolizing cytochrome P450s and also increased the clearance of the cytochrome P450 substrate zoxazolamine. This induction was com ...[more]