Deletion of methylglyoxal synthase gene (mgsA) increased sugar co-metabolism in ethanol-producing Escherichia coli.
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ABSTRACT:
SUBMITTER: Yomano LP
PROVIDER: S-EPMC2721133 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
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Deletion of methylglyoxal synthase gene (mgsA) increased sugar co-metabolism in ethanol-producing Escherichia coli.
Yomano L P LP York S W SW Shanmugam K T KT Ingram L O LO
Biotechnology letters 20090521 9
The use of lignocellulose as a source of sugars for bioproducts requires the development of biocatalysts that maximize product yields by fermenting mixtures of hexose and pentose sugars to completion. In this study, we implicate mgsA encoding methylglyoxal synthase (and methylglyoxal) in the modulation of sugar metabolism. Deletion of this gene (strain LY168) resulted in the co-metabolism of glucose and xylose, and accelerated the metabolism of a 5-sugar mixture (mannose, glucose, arabinose, xyl ...[more]
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