Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.
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ABSTRACT:
SUBMITTER: Rai G
PROVIDER: S-EPMC2721338 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
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Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.
Rai Ganesha G Thomas Craig J CJ Leister William W Maloney David J DJ
Tetrahedron letters 20090401 15
The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and anti-schistosomal activity. ...[more]
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