Ontology highlight
ABSTRACT:
SUBMITTER: Wallace DL
PROVIDER: S-EPMC2721778 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Wallace Deanna L DL Han Ming-Hu MH Graham Danielle L DL Green Thomas A TA Vialou Vincent V Iñiguez Sergio D SD Cao Jun-Li JL Kirk Anne A Chakravarty Sumana S Kumar Arvind A Krishnan Vaishnav V Neve Rachael L RL Cooper Don C DC Bolaños Carlos A CA Barrot Michel M McClung Colleen A CA Nestler Eric J EJ
Nature neuroscience 20090118 2
Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed by chronic, but not acute, antidepressant treatment. However, although the anxiety phenotype and its reversal by antidepressant treatment were CREB-dependent, the anhedonia-like sy ...[more]