Ontology highlight
ABSTRACT:
SUBMITTER: Graveel CR
PROVIDER: S-EPMC2722304 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Graveel Carrie R CR DeGroot Jack D JD Su Yanli Y Koeman Julie J Dykema Karl K Leung Samuel S Snider Jacqueline J Davies Sherri R SR Swiatek Pamela J PJ Cottingham Sandra S Watson Mark A MA Ellis Matthew J MJ Sigler Robert E RE Furge Kyle A KA Vande Woude George F GF
Proceedings of the National Academy of Sciences of the United States of America 20090630 31
Understanding the signaling pathways that drive aggressive breast cancers is critical to the development of effective therapeutics. The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer subtypes is unclear. We describe a knockin mouse with mutationally activated Met (Met(mut)) that develops a high incidence of diverse mammary tumors with basal characteristics, including metaplasia, absence of progesterone receptor and ER ...[more]