Ontology highlight
ABSTRACT:
SUBMITTER: Desplats P
PROVIDER: S-EPMC2722313 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Desplats Paula P Lee He-Jin HJ Bae Eun-Jin EJ Patrick Christina C Rockenstein Edward E Crews Leslie L Spencer Brian B Masliah Eliezer E Lee Seung-Jae SJ
Proceedings of the National Academy of Sciences of the United States of America 20090727 31
Neuronal accumulation of alpha-synuclein and Lewy body formation are characteristic to many neurodegenerative diseases, including Parkinson's disease (PD). This Lewy pathology appears to spread throughout the brain as the disease progresses. Furthermore, recent studies showed the occurrence of Lewy pathology in neurons grafted into the brains of PD patients, suggesting the spread of pathology from the host tissues to the grafts. The mechanism underlying this propagation is unknown. Here, we show ...[more]