Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
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ABSTRACT:
SUBMITTER: Mansoor N
PROVIDER: S-EPMC2722743 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Publications
Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life.
Mansoor Nazma N Abel Brian B Scriba Thomas J TJ Hughes Jane J de Kock Marwou M Tameris Michele M Mlenjeni Sylvia S Denation Lea L Little Francesca F Gelderbloem Sebastian S Hawkridge Anthony A Boom W Henry WH Kaplan Gilla G Hussey Gregory D GD Hanekom Willem A WA
Clinical immunology (Orlando, Fla.) 20081108 3
HIV-1 infection causes a severe T cell compromise; however, little is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7(+)CD45RA(+) naive CD8(+) T cells was significantly decreased, while the frequency of CCR7(-)CD45RA(-) effector memory ...[more]
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