Ontology highlight
ABSTRACT:
SUBMITTER: Rasmussen MH
PROVIDER: S-EPMC2724284 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Rasmussen Mads Heilskov MH Wang Bruce B Wabl Matthias M Nielsen Anders Lade AL Pedersen Finn Skou FS
Nucleic acids research 20090605 14
Retroviral insertional mutagenesis has been instrumental for the identification of genes important in cancer development. The molecular mechanisms involved in retroviral-mediated activation of proto-oncogenes influence the distribution of insertions within specific regions during tumorigenesis and hence may point to novel gene structures. From a retroviral tagging screen on tumors of 1767 SL3-3 MLV-infected BALB/c mice, intron 2 of the AP-1 repressor Jdp2 locus was found frequently targeted by p ...[more]