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Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.

ABSTRACT: Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.

SUBMITTER: Tavenet A

PROVIDER: S-EPMC2725013 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.

Tavenet Arounie A Suleau Audrey A Dubreuil Géraldine G Ferrari Roberto R Ducrot Cécile C Michaut Magali M Aude Jean-Christophe JC Dieci Giorgio G Lefebvre Olivier O Conesa Christine C Acker Joël J

Proceedings of the National Academy of Sciences of the United States of America 20090811 34

Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells. ...[more]

PMID: 19706510

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