Measuring and interpreting the selectivity of protein kinase inhibitors.
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ABSTRACT:
SUBMITTER: Smyth LA
PROVIDER: S-EPMC2725273 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Measuring and interpreting the selectivity of protein kinase inhibitors.
Smyth Lynette A LA Collins Ian I
Journal of chemical biology 20090606 3
Protein kinase inhibitors are a well-established class of clinically useful drugs, particularly for the treatment of cancer. Achieving inhibitor selectivity for particular protein kinases often remains a significant challenge in the development of new small molecules as drugs or as tools for chemical biology research. This review summarises the methodologies available for measuring kinase inhibitor selectivity, both in vitro and in cells. The interpretation of kinase inhibitor selectivity data i ...[more]
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