Ontology highlight
ABSTRACT:
SUBMITTER: Schramm VL
PROVIDER: S-EPMC2725438 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Schramm Vern L VL Gutierrez Jemy A JA Cordovano Grace G Basu Indranil I Guha Chandan C Belbin Thomas J TJ Evans Gary B GB Tyler Peter C PC Furneaux Richard H RH
Nucleic acids symposium series (2004) 20080101 52
Transition state structures can be derived from kinetic isotope effects and computational chemistry. Molecular electrostatic potential maps of transition states serve as blueprints to guide synthesis of transition state analogue inhibitors of target enzymes. 5'- Methylthioadenosine phosphorylase (MTAP) functions in the polyamine pathway by recycling methylthioadenosine (MTA) and maintaining cellular S-adenosylmethionine (SAM). Its transition state structure was used to guide synthesis of MT-DADM ...[more]