Ontology highlight
ABSTRACT:
SUBMITTER: Im SS
PROVIDER: S-EPMC2725716 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Im Seung-Soon SS Hammond Linda E LE Yousef Leyla L Nugas-Selby Cherryl C Shin Dong-Ju DJ Seo Young-Kyo YK Fong Loren G LG Young Stephen G SG Osborne Timothy F TF
Molecular and cellular biology 20090629 17
We generated a line of mice in which sterol regulatory element binding protein 1a (SREBP-1a) was specifically inactivated by insertional mutagenesis. Homozygous mutant mice were completely viable despite expressing SREBP-1a mRNA below 5% of normal, and there were minimal effects on expression of either SREBP-1c or -2. Microarray expression studies in liver, where SREBP-1a mRNA is 1/10 the level of the highly similar SREBP-1c, demonstrated that only a few genes were affected. The only downregulat ...[more]