Ontology highlight
ABSTRACT:
SUBMITTER: Winner M
PROVIDER: S-EPMC2726006 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Winner Millicent M Meier Jason J Zierow Swen S Rendon Beatriz E BE Crichlow Gregg V GV Riggs Randall R Bucala Richard R Leng Lin L Smith Ned N Lolis Elias E Trent John O JO Mitchell Robert A RA
Cancer research 20080901 18
Although chemokine and growth factor receptors are attractive and popular targets for cancer therapeutic intervention, structure-based targeting of the ligands themselves is generally not considered practical. New evidence indicates that a notable exception to this is macrophage migration inhibitory factor (MIF). MIF, an autocrine- and paracrine-acting cytokine/growth factor, plays a pivotal role in both the initiation and maintenance of neoplastic diseases. MIF possesses a nonphysiologic enzyma ...[more]