Structure and function of HCV IRES domains.
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ABSTRACT:
SUBMITTER: Lukavsky PJ
PROVIDER: S-EPMC2726286 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, I discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonic ...[more]
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