Ontology highlight
ABSTRACT:
SUBMITTER: Massaad CA
PROVIDER: S-EPMC2726352 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Massaad Cynthia A CA Washington Taneasha M TM Pautler Robia G RG Klann Eric E
Proceedings of the National Academy of Sciences of the United States of America 20090803 32
Alzheimer's disease (AD) is a neurodegenerative disease characterized by impaired cognitive function and the deposition of extracellular amyloid plaques and intracellular tangles. Although the proximal cause of AD is not well understood, it is clear that amyloid-beta (Abeta) plays a critical role in AD pathology. Recent studies also implicate mitochondrial abnormalities in AD. We investigated this idea by crossing mice that overexpress mitochondrial superoxide dismutase (SOD-2) with the Tg2576 m ...[more]