Ontology highlight
ABSTRACT:
SUBMITTER: Calabria E
PROVIDER: S-EPMC2726382 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Calabria Elisa E Ciciliot Stefano S Moretti Irene I Garcia Marta M Picard Anne A Dyar Kenneth A KA Pallafacchina Giorgia G Tothova Jana J Schiaffino Stefano S Murgia Marta M
Proceedings of the National Academy of Sciences of the United States of America 20090724 32
The intracellular signals that convert fast and slow motor neuron activity into muscle fiber type specific transcriptional programs have only been partially defined. The calcium/calmodulin-dependent phosphatase calcineurin (Cn) has been shown to mediate the transcriptional effects of motor neuron activity, but precisely how 4 distinct muscle fiber types are composed and maintained in response to activity is largely unknown. Here, we show that 4 nuclear factor of activated T cell (NFAT) family me ...[more]