Ontology highlight
ABSTRACT:
SUBMITTER: Kawajiri K
PROVIDER: S-EPMC2726415 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Kawajiri Kaname K Kobayashi Yasuhito Y Ohtake Fumiaki F Ikuta Togo T Matsushima Yoshibumi Y Mimura Junsei J Pettersson Sven S Pollenz Richard S RS Sakaki Toshiyuki T Hirokawa Takatsugu T Akiyama Tetsu T Kurosumi Masafumi M Poellinger Lorenz L Kato Shigeaki S Fujii-Kuriyama Yoshiaki Y
Proceedings of the National Academy of Sciences of the United States of America 20090727 32
Intestinal cancer is one of the most common human cancers. Aberrant activation of the canonical Wnt signaling cascade, for example, caused by adenomatous polyposis coli (APC) gene mutations, leads to increased stabilization and accumulation of beta-catenin, resulting in initiation of intestinal carcinogenesis. The aryl hydrocarbon receptor (AhR) has dual roles in regulating intracellular protein levels both as a ligand-activated transcription factor and as a ligand-dependent E3 ubiquitin ligase. ...[more]