No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
Ontology highlight
ABSTRACT: Aim
To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.Methods
We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.Results
None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer.Conclusion
Our study does not support PTEN as a colon cancer susceptibility gene.
SUBMITTER: Phillips LS
PROVIDER: S-EPMC2726455 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer.
Phillips Lynette S LS Thompson Cheryl L CL Merkulova Alona A Plummer Sarah J SJ Tucker Thomas C TC Casey Graham G Li Li L
World journal of gastroenterology 20090801 30
<h4>Aim</h4>To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer.<h4>Methods</h4>We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.<h4>Results</h4>None of the PTEN SNPs were statistically significantly associated with co ...[more]
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