Ontology highlight
ABSTRACT:
SUBMITTER: Pirngruber J
PROVIDER: S-EPMC2726677 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Pirngruber Judith J Shchebet Andrei A Schreiber Lisa L Shema Efrat E Minsky Neri N Chapman Rob D RD Eick Dirk D Aylon Yael Y Oren Moshe M Johnsen Steven A SA
EMBO reports 20090703 8
Post-translational histone modifications have essential roles in controlling nuclear processes; however, the specific mechanisms regulating these modifications and their combinatorial activities remain elusive. Cyclin-dependent kinase 9 (CDK9) regulates gene expression by phosphorylating transcriptional regulatory proteins, including the RNA polymerase II carboxy-terminal domain. Here, we show that CDK9 activity is essential for maintaining global and gene-associated levels of histone H2B monoub ...[more]