Ontology highlight
ABSTRACT:
SUBMITTER: Gilbert PB
PROVIDER: S-EPMC2726718 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Biometrics 20080324 4
<h4>Summary</h4>Frangakis and Rubin (2002, Biometrics 58, 21-29) proposed a new definition of a surrogate endpoint (a "principal" surrogate) based on causal effects. We introduce an estimand for evaluating a principal surrogate, the causal effect predictiveness (CEP) surface, which quantifies how well causal treatment effects on the biomarker predict causal treatment effects on the clinical endpoint. Although the CEP surface is not identifiable due to missing potential outcomes, it can be identi ...[more]