Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC2726827 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Wang Qianben Q Li Wei W Zhang Yong Y Yuan Xin X Xu Kexin K Yu Jindan J Chen Zhong Z Beroukhim Rameen R Wang Hongyun H Lupien Mathieu M Wu Tao T Regan Meredith M MM Meyer Clifford A CA Carroll Jason S JS Manrai Arjun Kumar AK Jänne Olli A OA Balk Steven P SP Mehra Rohit R Han Bo B Chinnaiyan Arul M AM Rubin Mark A MA True Lawrence L Fiorentino Michelangelo M Fiore Christopher C Loda Massimo M Kantoff Philip W PW Liu X Shirley XS Brown Myles M
Cell 20090701 2
The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its function in androgen-independent cancers is poorly understood. We have defined the direct AR-dependent target genes in both androgen-dependent and -independent cancer cells by generating AR-dependent gene expression profiles and AR cistromes. In contrast to what is found in androgen-dependent cells, AR sele ...[more]