Lowly expressed human microRNA genes evolve rapidly.
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ABSTRACT:
SUBMITTER: Liang H
PROVIDER: S-EPMC2727378 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Publications
Lowly expressed human microRNA genes evolve rapidly.
Molecular biology and evolution 20090319 6
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that approximately 30% of currently annotated human miRNA genes are almost free of selective pressure. ...[more]
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