Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC2727637 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Tang Yi Y Wu Xiangwei X Lei Weiqi W Pang Lijuan L Wan Chao C Shi Zhenqi Z Zhao Ling L Nagy Timothy R TR Peng Xinyu X Hu Junbo J Feng Xu X Van Hul Wim W Wan Mei M Cao Xu X
Nature medicine 20090705 7
Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this process are associated with skeletal diseases, such as Camurati-Engelmann disease (CED). We show using in vitro and in vivo models that active TGF-beta1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to the bone resorptive sites and that this process is mediated through ...[more]