Ontology highlight
ABSTRACT:
SUBMITTER: Fletcher O
PROVIDER: S-EPMC2727696 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Fletcher Olivia O Johnson Nichola N Dos Santos Silva Isabel I Kilpivaara Outi O Aittomäki Kristiina K Blomqvist Carl C Nevanlinna Heli H Wasielewski Marijke M Meijers-Heijerboer Hanne H Broeks Annegien A Schmidt Marjanka K MK Van't Veer Laura J LJ Bremer Michael M Dörk Thilo T Chekmariova Elena V EV Sokolenko Anna P AP Imyanitov Evgeny N EN Hamann Ute U Rashid Muhammad U MU Brauch Hiltrud H Justenhoven Christina C Ashworth Alan A Peto Julian J
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090101 1
If breast cancers arise independently in each breast the odds ratio (OR) for bilateral breast cancer for carriers of CHEK2 1100delC should be approximately 5.5, the square of the reported OR for a first primary (OR, 2.34). In the subset of bilateral cases with one or more affected relatives, the predicted carrier OR should be approximately 9. We have tested these predictions in a pooled set of 1,828 cases with 2 primaries and 7,030 controls from 8 studies. The second primary OR for CHEK2 1100del ...[more]