Ontology highlight
ABSTRACT:
SUBMITTER: Lariviere FJ
PROVIDER: S-EPMC2727856 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Lariviere Frederick J FJ Newman Adam G AG Watts Megan L ML Bradley Sharonda Q SQ Juskewitch Justin E JE Greenwood Paul G PG Millard Julie T JT
Mutation research 20090221 1-2
The bifunctional alkylating agents diepoxybutane (DEB) and epichlorohydrin (ECH) are linked to the elevated incidence of certain cancers among workers in the synthetic polymer industry. Both compounds form interstrand cross-links within duplex DNA, an activity suggested to contribute to their cytotoxicity. To assess the DNA targeting of these compounds in vivo, we assayed for damage within chicken erythro-progenitor cells at three different sites: one within mitochondrial DNA, one within express ...[more]