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Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS.

ABSTRACT: Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.

SUBMITTER: Park J

PROVIDER: S-EPMC2728619 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Disruption of Nectin-like 1 cell adhesion molecule leads to delayed axonal myelination in the CNS.

Park Jinsil J Liu Ben B Chen Tao T Li Hong H Hu Xuemei X Gao Jing J Zhu Ying Y Zhu Qiang Q Qiang Boqin B Yuan Jiangang J Peng Xiaozhong X Qiu Mengsheng M

The Journal of neuroscience : the official journal of the Society for Neuroscience 20081101 48

Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expres ...[more]

PMID: 19036974

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