Ontology highlight
ABSTRACT:
SUBMITTER: Bernardo SM
PROVIDER: S-EPMC2729247 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Bernardo Stella M SM Khalique Zachary Z Kot John J Jones Jason K JK Lee Samuel A SA
Fungal genetics and biology : FG & B 20080126 6
To investigate the pre-vacuolar secretory pathway in Candida albicans, we cloned and analyzed the C. albicans homolog of the Saccharomyces cerevisiae vacuolar protein sorting gene VPS1. C. albicans VPS1 encodes a predicted 694-aa dynamin-like GTPase that is 73.3% similar to S. cerevisiae Vps1p. Plasmids bearing C. albicans VPS1 complemented the temperature-sensitive growth, abnormal class F vacuolar morphology, and carboxypeptidase missorting of a S. cerevisiae vps1 null mutant. To study VPS1 fu ...[more]