Persuading natural killer cells to eliminate bad B cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Cooper LJ
PROVIDER: S-EPMC2730884 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Persuading natural killer cells to eliminate bad B cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 20090728 15
Clinical trials are underway infusing T cells genetically modified to be specific for B-cell malignancies using a chimeric antigen receptor (CAR) to redirect specificity for CD19. However, issues remain about whether the CAR can provide a fully competent application signal and whether other lymphocytes with lytic capacity can target CD19(+) tumors. ...[more]
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